Preheat Oven to 250 degrees F. Line a baking sheet with aluminum foil.
Combine the Worcestershire sauce, butter, and liquid smoke in a medium bowl. Add the pecans and stir to coat. In a small bowl, combine the onion powder, garlic powder, seasoning salt, sugar, and cayenne. Sprinkle half the spice mixture over the nuts and stir well. Add the remaining spice mixture and stir again.
Spread the nuts in a single layer on the prepared baking sheet and bake until the nuts are dry and toasted, 30 to 40 minutes. Let cool completely before serving!!!