New research regarding Implantation Failure
Dr. Carter Says Semen Cause of Implantation Failure
January 28 2005 at 2:10 AM Olive
--------------------------------------------------------------------------------
saw this on another bb
----------------
Thanks for alerting us to this. I was able to copy the text. All
credit for this goes to NORA. You can subscribe to this by visitng
Dr. Carter's website. multiplemiscarriage.com (no www)
Our First Newsletter
Thank you for contacting us and expressing interest in our
newsletter. The concept behind our newsletter is to periodically
provide couples with insights into recent advances being made into
the application of immunology to reproductive health. Our patient
community is extraordinarily sharp and has accumulated substantial
research on its own. We hope to share with you every month one topic
that we believe should be of interest to you and that may not have
been easily accessible to you using your own research tools. We are
very excited about our first topic, which briefly explores the role
of the male immune system in implantation. Thank you again for your
interest in what we are doing. Please reach us at [email protected] if
you have any questions or suggestions.
Male Immunity and Recurrent Miscarriage
and Implantation Failure
Our attention has recently turned to the male immune system in IVF
implantation failure and early recurrent miscarriage. There is a
significant body of data compiled over the last ten years showing
that seminal fluid plays a critical role in supporting implantation
and placental development. Seminal fluid is a complex mixture of
cells and chemical compounds. The cellular component of the seminal
fluid is primarily comprised of cells derived from the blood. These
include natural killer cells (NK cells) and T cells. Likewise the
chemical components of seminal fluid are derived from blood and
consist, in part, of cytokines and other important immune mediators.
It is becoming clear that pro-inflammatory seminal fluid can create a
hostile environment for implantation. For example, several studies
have independently shown that the defining Th1 cytokine, gamma
interferon, is frequently present in the seminal fluid of infertile
men. Another interesting and consistent finding is that the
immunosuppressive cytokines IL-10 and transforming growth factorbeta
(TGF-beta) are reduced in the seminal fluid of infertile men. What
has been left largely unexplored are the mechanisms that exist to
prevent immunocompetent T cells and NK cells contained in seminal
fluid from destroying the immunologically foreign implantation site.
Such mechanisms do in fact exist and we are beginning to understand
how these factors contribute to successful implantation.
Unfortunately a standard workup for miscarriage and implantation
failure rarely, if ever, includes immune evaluation for the male
sexual partner. This is a major shortcoming. As of March 2005, we
will begin to address the role of the male immune system in pregnancy
failure through a new testing battery and treatment. Because the
seminal fluid is a filtrate of the blood plasma, a simple blood test
is the entry point for this testing battery. Even couples that have
had extensive male factor testing could benefit from this protocol.
Please contact us at [email protected] if you are interested in
learning more.
January 28 2005 at 2:10 AM Olive
--------------------------------------------------------------------------------
saw this on another bb
----------------
Thanks for alerting us to this. I was able to copy the text. All
credit for this goes to NORA. You can subscribe to this by visitng
Dr. Carter's website. multiplemiscarriage.com (no www)
Our First Newsletter
Thank you for contacting us and expressing interest in our
newsletter. The concept behind our newsletter is to periodically
provide couples with insights into recent advances being made into
the application of immunology to reproductive health. Our patient
community is extraordinarily sharp and has accumulated substantial
research on its own. We hope to share with you every month one topic
that we believe should be of interest to you and that may not have
been easily accessible to you using your own research tools. We are
very excited about our first topic, which briefly explores the role
of the male immune system in implantation. Thank you again for your
interest in what we are doing. Please reach us at [email protected] if
you have any questions or suggestions.
Male Immunity and Recurrent Miscarriage
and Implantation Failure
Our attention has recently turned to the male immune system in IVF
implantation failure and early recurrent miscarriage. There is a
significant body of data compiled over the last ten years showing
that seminal fluid plays a critical role in supporting implantation
and placental development. Seminal fluid is a complex mixture of
cells and chemical compounds. The cellular component of the seminal
fluid is primarily comprised of cells derived from the blood. These
include natural killer cells (NK cells) and T cells. Likewise the
chemical components of seminal fluid are derived from blood and
consist, in part, of cytokines and other important immune mediators.
It is becoming clear that pro-inflammatory seminal fluid can create a
hostile environment for implantation. For example, several studies
have independently shown that the defining Th1 cytokine, gamma
interferon, is frequently present in the seminal fluid of infertile
men. Another interesting and consistent finding is that the
immunosuppressive cytokines IL-10 and transforming growth factorbeta
(TGF-beta) are reduced in the seminal fluid of infertile men. What
has been left largely unexplored are the mechanisms that exist to
prevent immunocompetent T cells and NK cells contained in seminal
fluid from destroying the immunologically foreign implantation site.
Such mechanisms do in fact exist and we are beginning to understand
how these factors contribute to successful implantation.
Unfortunately a standard workup for miscarriage and implantation
failure rarely, if ever, includes immune evaluation for the male
sexual partner. This is a major shortcoming. As of March 2005, we
will begin to address the role of the male immune system in pregnancy
failure through a new testing battery and treatment. Because the
seminal fluid is a filtrate of the blood plasma, a simple blood test
is the entry point for this testing battery. Even couples that have
had extensive male factor testing could benefit from this protocol.
Please contact us at [email protected] if you are interested in
learning more.
